658 research outputs found
Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease
- Author
- Abel LC
- Ana M Castro
- Bahia-Oliveira LM
- Briere F
- Camargo ME
- Cerban FM
- Cordeiro FD
- Correa-Oliveira R
- Daniela A D'Ávila
- Dutra WO
- Dutra WO
- Dutra WO
- Egler Chiari
- Eliane D Gontijo
- Fanger MW
- Ferreira RC
- Gaze ST
- Giordanengo L
- Gomes JA
- Gomes JA
- Guedes PM
- Higuchi ML
- Holscher C
- Kawano Y
- Lúcia MC Galvão
- Michailowsky V
- Moretti E
- Morgan J
- Paulo MM Guedes
- Perez-Fuentes R
- Perez-Fuentes R
- Ribeirao M
- Silva JS
- Talvani A
- Tibbetts RS
- Voller A
- Ward LS
- Watthanakulpanich D
- Zhang L
- Publication venue
- Instituto Oswaldo Cruz, Ministério da Saúde
- Publication date
- 01/02/2009
- Field of study
Get PDFThe immune response is crucial for protection against disease; however, immunological imbalances can lead to heart and digestive tract lesions in chagasic patients. Several studies have evaluated the cellular and humoral immune responses in chagasic patients in an attempt to correlate immunological findings with clinical forms of Chagas disease. Moreover, immunoglobulins and cytokines are important for parasitic control and are involved in lesion genesis. Here, cytokine and IgG isotype production were studied, using total epimastigote antigen on sera of chagasic patients with indeterminate (IND, n = 27) and cardiac (CARD, n = 16) forms of the disease. Samples from normal, uninfected individuals (NI, n = 30) were use as controls. The results showed that sera from both IND and CARD patients contained higher levels of Trypanosoma cruzi-specific IgG1 (IgG1) antibodies than sera from NI. No difference in IgG2 production levels was observed between NI, IND and CARD patients, nor was a difference in IL-10 and IFN-³ production detected in the sera of IND, CARD and NI patients. However, IND patients displayed a positive correlation between IL-10 and IFN-³ levels in serum, while CARD patients showed no such correlation, indicating an uncontrolled inflammatory response in CARD patients. These findings support the hypothesis that a lack of efficient regulation between IFN-³ and IL-10 productions in CARD patients may lead to cardiac immunopathology.CNP
IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter
- Author
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Get PDFRadiotherapy for head and neck tumors often results in persistent loss of function in salivary glands. Patients suffering from impaired salivary function frequently terminate treatment prematurely because of reduced quality of life caused by malnutrition and other debilitating side-effects. It has been previously shown in mice expressing a constitutively active form of Akt (myr-Akt1), or in mice pretreated with IGF1, apoptosis is suppressed, which correlates with maintained salivary gland function measured by stimulated salivary flow. Induction of cell cycle arrest may be important for this protection by allowing cells time for DNA repair. We have observed increased accumulation of cells in G2/M at acute time-points after irradiation in parotid glands of mice receiving pretreatment with IGF1. As p21, a transcriptional target of the p53 family, is necessary for maintaining G2/M arrest, we analyzed the roles of p53 and p63 in modulating IGF1-stimulated p21 expression. Pretreatment with IGF1 reduces binding of ΔNp63 to the p21 promoter after irradiation, which coincides with increased p53 binding and sustained p21 transcription. Our data indicate a role for ΔNp63 in modulating p53-dependent gene expression and influencing whether a cell death or cell cycle arrest program is initiated
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
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- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
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- Zanzi D
- Zeitnitz C
- Zeman M
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- Zenin O
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- Zerwas D
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- Zhao Z
- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Get PDFThe results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
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- Abdallah J
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- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
- Ye S
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
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- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
Get PDFA search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles R
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 01/01/2012
- Field of study
Get PDFThe ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
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- Zaidan R
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- Zambito S
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- Zanzi D
- Zaytsev A
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- Zemla A
- Zenin O
- Zeniš T
- Zerwas D
- Zevi Della Porta G
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- Zhao Z
- Zhemchugov A
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- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
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- Zmouchko VV
- Zobernig G
- Zoccoli A
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- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Get PDFTwo-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
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- Altheimer A
- Alviggi MG
- Amako K
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- Black CW
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- Castillo IS
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- Castro NF
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- Escalier M
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- Esch H
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- Escobar C
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- Espinal Curull X
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- Esposito B
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- Etienne F
- Etienne F
- Etienvre AI
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- Etzion E
- Etzion E
- Evans H
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- Fabbri L
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- Facini G
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- Fakhrutdinov RM
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- Faltova J
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- Fang Y
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- Farooque T
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- Farrell S
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- Farrington SM
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- Farthouat P
- Farthouat P
- Fassi F
- Fassi F
- Fassnacht P
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- Fassouliotis D
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- Favareto A
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- Fayard L
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- Federic P
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- Fedin OL
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- Fedorko W
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- Fehling-Kaschek M
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- Feigl S
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- Feligioni L
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- Feng C
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- Feng EJ
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- Feng H
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- Fenyuk AB
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- Fernando W
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- Ferrag S
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- Ferrando BMS
- Ferrando J
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- Ferrara V
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- Ferrari A
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- Ferrari P
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- Fiedler F
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- Filipcic A
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- Filipuzzi M
- Filipuzzi M
- Filthaut F
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- Fincke-Keeler M
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- Fiorini L
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- Fisher MJ
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- Fitzgerald EA
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- Fleck I
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- Fleischmann P
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- Fleischmann S
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- Fletcher G
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- Floderus A
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- Florez Bustos AC
- Flowerdew MJ
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- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
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- Fournier D
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- Fox H
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- Francavilla P
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- Francis D
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- Franklin M
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- Franz S
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- Fraternali M
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- Fratin S
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- French ST
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- Friedrich C
- Friedrich F
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- Galhardo B
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- Gallo V
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- Gallop BJ
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- Garelli N
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- Gatti C
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- Gavrilenko IL
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- Ge P
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- Gecse Z
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- Gee CNP
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- Geich-Gimbel C
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- Gemme C
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- Genest MH
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- Gentile S
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- George M
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- Gerbaudo D
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- Gershon A
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- Ghazlane H
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- Ghodbane N
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- Giacobbe B
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- Giangiobbe V
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- Giannetti P
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- Giokaris N
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- Giordani MP
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- Giordano R
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- Giugni D
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
Get PDFThis paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
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- Youssef S
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- Zhemchugov A
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- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Get PDFThe ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families
- Author
- A Broeks
- A de Klein
- A Liu
- A Moisan
- A Renwick
- AA Goodarzi
- AC Antoniou
- AC Antoniou
- AC Antoniou
- AC Antoniou
- AR Venkitaraman
- AR Venkitaraman
- B Devlin
- B Kuschel
- B Vogelstein
- Bernard Lespérance
- BL Weber
- C Burge
- CHEK2 Breast Cancer Case-Control Consortium
- CI Szabo
- D Avard
- D Thompson
- D Thompson
- D Thompson
- Damian Labuda
- DE Reich
- DF Easton
- DR Schmidt
- EJ Brown
- F Durocher
- FM Giardiello
- Francine Durocher
- G Chenevix-Trench
- GC Johnson
- Geneviève Ouellette
- GK Alderton
- H Meijers-Heijboer
- H Vezina
- H Zhao
- H Zhong
- IM Ward
- J Fortin
- J Peto
- J Peto
- Jacques Simard
- JC Barrett
- Jean Lépine
- JK Pritchard
- JK Pritchard
- JL Mannino
- JN Hirschhorn
- Jocelyne Chiquette
- K Ding
- K Heikkinen
- K Ueda
- KE Lohmueller
- L Zou
- M Cargill
- M Dorval
- M Gasco
- M O'Driscoll
- M Stephens
- M Swift
- Marie Plante
- ME Weale
- N Foray
- NS Fearnhead
- Olga Sinilnikova
- OM Sinilnikova
- P Boukamp
- P Boukamp
- P Lichtenstein
- P Pichierri
- Paul Bessette
- PD Pharoah
- PD Pharoah
- Penny Soucy
- Q Liu
- Rachel Laframboise
- RC Lewontin
- Roxane Pichette
- RS Houlston
- RS Tibbetts
- RS Tibbetts
- SB Gabriel
- Sean V Tavtigian
- T Stankovic
- V Bonadona
- V Luu-The
- WY Wang
- WY Wang
- YR Thorstenson
- Yvan Labrie
- Publication venue
- BioMed Central
- Publication date
- 01/09/2006
- Field of study
Get PDFBACKGROUND: Ataxia telangiectasia-mutated and Rad3-related (ATR) is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. METHODS: ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD), haplotype analyses, and tagging SNP (tSNP) identification. Expression analyses were carried out using real-time PCR. RESULTS: The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. CONCLUSION: Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association studies. In addition, our study led to the characterization of a novel Δ33 splice form, which could generate a putative truncated protein lacking several functional domains. Additional studies in large cohorts and other populations will be needed to further evaluate if common and/or rare ATR sequence variants can be associated with a modest or intermediate breast cancer risk
DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells
- Author
- AC Fluckiger
- AH Hart
- CA Banuelos
- CA Sommer
- Charles Easley
- CJ Bakkenist
- CW Anderson
- DK Singh
- E Meshorer
- ED Tichy
- ED Tichy
- EP Rogakou
- EP Rogakou
- G Li
- Gerald Schatten
- H Hong
- H Li
- I Chambers
- J Nichols
- J Utikal
- J Yu
- JA Thomson
- Jamie Fornsaglio
- JP Banath
- K Hochedlinger
- K Mitsui
- K Okita
- K Takahashi
- K Takahashi
- KA Becker
- L Serrano
- LA Boyer
- Leah Knobloch
- Maurizio C. Capogrossi
- MI Aladjem
- NH Chehab
- NJ Finnie
- O Momcilovic
- Olga Momcilovic
- RS Tibbetts
- RT Abraham
- S Maynard
- Sandra Varum
- T Kawamura
- W Deng
- Y Hong
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2010
- Field of study
Get PDFBACKGROUND: Induced pluripotent stem (iPS) cells have the capability to undergo self-renewal and differentiation into all somatic cell types. Since they can be produced through somatic cell reprogramming, which uses a defined set of transcription factors, iPS cells represent important sources of patient-specific cells for clinical applications. However, before these cells can be used in therapeutic designs, it is essential to understand their genetic stability.\ud
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METHODOLOGY/PRINCIPAL FINDINGS: Here, we describe DNA damage responses in human iPS cells. We observe hypersensitivity to DNA damaging agents resulting in rapid induction of apoptosis after γ-irradiation. Expression of pluripotency factors does not appear to be diminished after irradiation in iPS cells. Following irradiation, iPS cells activate checkpoint signaling, evidenced by phosphorylation of ATM, NBS1, CHEK2, and TP53, localization of ATM to the double strand breaks (DSB), and localization of TP53 to the nucleus of NANOG-positive cells. We demonstrate that iPS cells temporary arrest cell cycle progression in the G(2) phase of the cell cycle, displaying a lack of the G(1)/S cell cycle arrest similar to human embryonic stem (ES) cells. Furthermore, both cell types remove DSB within six hours of γ-irradiation, form RAD51 foci and exhibit sister chromatid exchanges suggesting homologous recombination repair. Finally, we report elevated expression of genes involved in DNA damage signaling, checkpoint function, and repair of various types of DNA lesions in ES and iPS cells relative to their differentiated counterparts.\ud
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CONCLUSIONS/SIGNIFICANCE: High degrees of similarity in DNA damage responses between ES and iPS cells were found. Even though reprogramming did not alter checkpoint signaling following DNA damage, dramatic changes in cell cycle structure, including a high percentage of cells in the S phase, increased radiosensitivity and loss of DNA damage-induced G(1)/S cell cycle arrest, were observed in stem cells generated by induced pluripotency.\ud
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