187 research outputs found
Proportional Hazard Bivariate Kumaraswamy Model Applied on Fish Mercury Concentration
Get PDFInternational advisory bodies have developed guidelines for testing mercury and aquatic items to protect human health and international trade. The mercury absorption in fish has a great effect on human health. For modeling this problem, a new bivariate distribution using the proportional hazard rate (PHR) model with Kumaraswamy marginal called BKPH is derived and studied via statistical properties and reliability measures. Moreover, several methods of parameter estimation are discussed, including maximum likelihood estimation (MLE), method of moments estimation (MME), and inference function for margins estimation (IFM). In the simulation study, the performance of estimators depending on their estimation methodologies is compared. Finally, a comparative study of the proposed BKPH with several bivariate Kumaraswamy distributions via goodness of fit criteria was introduced. The results of the study proved the potentiality of the BKPH model and has a best fitting on mercury fish absorption data
Photoelectron imaging and theoretical investigation of bimetallic Bi1â2Gaâ0â2 and Pbâ1â4 cluster anions
Get PDFWe present the results of photoelectron velocity-map imaging experiments for the photodetachment of small negatively charged BimGan (m=1â2, n=0â2), and Pbn (n=1â4) clusters at 527 nm. The photoelectron images reveal new features along with their angular distributions in the photoelectron spectra of these clusters. We report the vertical detachment energies of the observed multiple electronic bands and their respective anisotropy parameters for the BimGan and Pbn clusters derived from the photoelectron images. Experiments on the BiGan clusters reveal that the electron affinity increases with the number of Ga atoms from n=0 to 2. The BiGaâ2 cluster is found to be stable, both because of its even electron number and the high electron affinity of BiGa2. The measured photoelectron angular distributions of the BimGan and Pbn clusters are dependent on both the orbital symmetry and electron kinetic energies. Density-functional theory calculations employing the generalized gradient approximation for the exchange-correlation potential were performed on these clusters to determine their atomic and electronic structures. From the theoretical calculations, we find that the BiGaâ2, Bi2Gaâ3 and Bi2Gaâ5 (anionic), and BiGa3, BiGa5, Bi2Ga4 and Bi2Ga6(neutral) clusters are unusually stable. The stability of the anionic and neutral Bi2Gan clusters is attributed to an even-odd effect, with clusters having an even number of electrons presenting a larger gain in energy through the addition of a Ga atom to the preceding size compared to odd electron systems. The stability of the neutral BiGa3 cluster is rationalized as being similar to BiAl3, an all-metal aromatic cluster
Ancient Egypt 1923 Part 1
Get PDFPart 1 of the 1923 Ancient Egypt books. Contents include a portrait of Menkaura, the magic skin, and customs at childbirth.https://knowledge.e.southern.edu/kweeks_coll/1022/thumbnail.jp
CASSAVA ADDITION FOR AMYGDALIN ENRICHMENT IN DAIRY BEVERAGES
Get PDFThe cassava plant is known for its numerous medicinal and nutritional benefits. This study used cassava to enhance the nutritional content of milk and enrich it with amygdalin (vitamin B17). Properties associated with amygdalin include anticoagulants, atherosclerotic, hepatic protective, anti-tumor, antidiabetic, antifungal, anti-inflammatory, anticancer, antibacterial, anti-aging, and antioxidants. Cassava paste was prepared by boiling its roots in water for 1 hour and subsequently mashing them. Raw cow’s milk, 5 % sugar, and 1 sachet of vanilla (1 gm) were mixed and heated at 80°C for 10 minutes. Fresh and refrigerated samples were tested for amygdalin concentrations at 6 ± 1°C. The amygdalin content in 5% cassava milk was 3.51 ± 0.01 mg/100 g and 3.52 ± 0.01 after 1 week of refrigeration (6± 1°C). Whereas, for 10% cassava milk it increased from 7.01 ± 0.01 mg/100 g when freshly prepared to 7.02 ± 0.02 after 1week’s refrigeration at 6 ± 1°C. This slight increase could be attributed to water evaporation during the one-week refrigeration
Symbolic analysis of analog circuits containing voltage mirrors
Get PDF7 pĂĄginas, 7 figuras, 2 tablas, 4 imĂĄgenes.-- Open Access: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License.The pathological elements voltage mirror (VM) and current mirror (CM) have shown advantages in analog behavioral modeling and circuit synthesis, where many nullor-mirror equivalences have been explored to design and to transform voltage-mode circuits to current-mode ones and viceversa. However, both the VM and CM have not equivalents to perform automatic symbolic circuit analysis. In this manner, we introduce nullor-equivalents for these pathological elements allowing to include parasitics and to perform only symbolic nodal analysis. The nullor-equivalent of the CM is extended to provide multiple-outpus (MO-CM). Finally, two active filters containing VMs, CMs and MO-CMs are analysed to show the usefulness of the models.This work is supported by: UC-MEXUS and
CONACyT under grants CN-09-310 and 48396-Y; by Promep-Mexico under grant UATLX-PTC-088; by Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia-Spain TIC-2532; and by the
JAE-Doc program of CSIC co-funded by FSE, Spain.Peer reviewe
A bioinformatics pipeline to search functional motifs within whole-proteome data: a case study of poxviruses
Full text linkCryo-EM structure of human Pol Îș bound to DNA and mono-ubiquitylated PCNA
Get PDFY-family DNA polymerase Îș (Pol Îș) can replicate damaged DNA templates to rescue stalled replication forks. Access of Pol Îș to DNA damage sites is facilitated by its interaction with the processivity clamp PCNA and is regulated by PCNA mono-ubiquitylation. Here, we present cryo-EM reconstructions of human Pol Îș bound to DNA, an incoming nucleotide, and wild type or mono-ubiquitylated PCNA (Ub-PCNA). In both reconstructions, the internal PIP-box adjacent to the Pol Îș Polymerase-Associated Domain (PAD) docks the catalytic core to one PCNA protomer in an angled orientation, bending the DNA exiting the Pol Îș active site through PCNA, while Pol Îș C-terminal domain containing two Ubiquitin Binding Zinc Fingers (UBZs) is invisible, in agreement with disorder predictions. The ubiquitin moieties are partly flexible and extend radially away from PCNA, with the ubiquitin at the Pol Îș-bound protomer appearing more rigid. Activity assays suggest that, when the internal PIP-box interaction is lost, Pol Îș is retained on DNA by a secondary interaction between the UBZs and the ubiquitins flexibly conjugated to PCNA. Our data provide a structural basis for the recruitment of a Y-family TLS polymerase to sites of DNA damage.This research was supported by King Abdullah University of Science and Technology through core funding (to S.M.H.) and the Competitive Research Award Grant CRG8 URF/1/4036â01â01 (to S.M.H. and A.D.B.), and by the Wellcome Trust (to A.D.B.). R.C. acknowledges funding from the MINECO (CTQ2016-78636-P) and to AGAUR, (2017 SGR 324). The MD project has been carried out using CSUC resources. We acknowledge The Midlands Regional Cryo-EM Facility at the Leicester Institute of Structural and Chemical Biology (LISCB), major funding from MRC (MC_PC_17136). We thank Christos Savva (LISCB, University of Leicester) for his help in cryo-EM data collection and advice on data processing.Peer reviewe
Drug susceptibility profiles of pulmonary Mycobacterium tuberculosis isolates from patients in informal urban settlements in Nairobi, Kenya
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