302 research outputs found
Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas.
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Limitations of Tc99m-MIBI-SPECT Imaging Scans in Persistent Primary Hyperparathyroidism
Get PDFIn primary hyperparathyroidism (PHPT) the predictive value of technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT) for localizing pathological parathyroid glands before a first parathyroidectomy (PTx) is 83-100%. Data are scarce in patients undergoing reoperative parathyroidectomy for persistent hyperparathyroidism. The aim of the present study was to determine the value of Tc99m-MIBI-SPECT in localizing residual hyperactive parathyroid tissue in patients with persistent primary hyperparathyroidism (PHPT) after initial excision of one or more pathological glands. We retrospectively evaluated the localizing accuracy of Tc99m-MIBI-SPECT scans in 19 consecutive patients with persistent PHPT who had a scan before reoperative parathyroidectomy. We used as controls 23 patients with sporadic PHPT who had a scan before initial surgery. In patients with persistent PHPT, Tc99m-MIBI-SPECT accurately localized a pathological parathyroid gland in 33% of cases before reoperative parathyroidectomy, compared to 61% before first PTx for sporadic PHPT. The Tc99m-MIBI-SPECT scan accurately localized intra-thyroidal glands in 2 of 7 cases and a mediastinal gland in 1 of 3 cases either before initial or reoperative parathyroidectomy. Our data suggest that the accuracy of Tc99m-MIBI-SPECT in localizing residual hyperactive glands is significantly lower before reoperative parathyroidectomy for persistent PHPT than before initial surgery for sporadic PHPT. These findings should be taken in consideration in the preoperative workup of patients with persistent primary hyperparathyroidis
Endocrine cells and nerve ganglia of the small intestine of the Opossum Didelphis aurita Wied-Neuwied, 1826 (Mammalia: Didelphidae)
Get PDFThe nervous and endocrine systems jointly control intestinal movements, secretions of their glands and also participate of the processes of nutrient digestion and absorption. Therefore, the central objective of this study was to verify the existence of a possible relationship between the number of nervous cells and ganglia of the submucosal and myenteric plexuses and the number of endocrine cells in the small intestine of adult D. aurita. The utilized staining techniques were Grimelius, modified Masson-Fontana, direct immunoperoxidase and H-E. Argyrophillic, argentaffin and insulin immunoreactive endocrine cells do not numerically vary between the initial, mid and final regions of the duodenum, jejunum and ileum (P>0.05), except for argyrophillic cells in the jejunum (P>0.05). No numerical relationship has yet been verified between the number of nerve ganglia and endocrine cells, and also between nervous and endocrine cells. We recommended the use of new immunohistochemical techniques to confirm the numerical correlation between the nervous and endocrine systems in the small intestine. The morphology and distribution of endocrine cells and the nerve ganglia studied were similar to those encountered in eutherian mammals.Os sistemas nervoso e endĂłcrino controlam integra-damente os movimentos intestinais, a secreção de suas glĂąndulas e tambĂ©m participam dos processos de digestĂŁo e absorção de nutrientes. Portanto, o objetivo central deste estudo foi verificar a existĂȘncia de uma possĂvel relação entre o nĂșmero de cĂ©lulas nervosas e gĂąnglios dos plexos submucosos e mioentĂ©ricos e o nĂșmero de cĂ©lulas endĂłcrinas no intestino delgado de adultos de D. aurita. As tĂ©cnicas de coloração utilizadas foram Grimelius, Masson-Fontana modificada, imunoperoxidase direta e H-E. As cĂ©lulas endĂłcrinas argirĂłfilas, argentafins e imunorreativas Ă insulina nĂŁo variaram numericamente entre as regiĂ”es inicial, mĂ©dia e final do duodeno, jejuno e Ăleo (P>0,05), exceto as cĂ©lulas argirĂłfilas no jejuno (P<0,05). Nenhuma relação numĂ©rica foi verificada entre o nĂșmero de gĂąnglios nervosos e cĂ©lulas endĂłcrinas, e tambĂ©m entre cĂ©lulas nervosas e endĂłcrinas. NĂłs recomendamos o emprego de novas tĂ©cnicas imunohistoquĂmicas para confirmar a correlação numĂ©rica entre os sistemas nervoso e endĂłcrino no intestino delgado. A morfologia e a distribuição das cĂ©lulas endĂłcrinas e dos gĂąnglios nervosos estudados foram similares Ă queles encontrados em mamĂferos eutĂ©rios
Regulatory peptides in gut endocrine cells and nerves in the starfish Marthasterias glacialis
Full text linkThe presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density
Full text linkDeterminação do sistema endĂłcrino difuso nos intestinos de trĂȘs Teleostei (Pisces) de ĂĄgua doce com hĂĄbitos alimentares diferentes
Full text linkLars Grimelius and his silver impregnation methodâCommentaries on the paper in Upsala Journal of Medical Sciences
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