48 research outputs found
Glaucoma Detection by Learning from Multiple Informatics Domains
Get PDFWe present a comprehensive and fully automatic glaucoma detection approach that uses machine learning techniques over multiple informatics domains, consisting of personal profile data, genetic data, and retinal image data. This approach, referred to as MKLclm, enriches the feature set of the multiple kernel learning (MKL) framework through the incorporation of classemes, which represent the outputs of multiple class-specific classifiers trained from the data of each informatics domain. We validate our MKLclm framework on a population- based dataset consisting of 2258 subjects, achieving an AUC of 94.9% ± 1.7% and a specificity of 88.5% ± 2.7% at 85% sensitivity, which is significantly better than the current clinical standard of care which uses intraocular pressure (IOP) for glaucoma detection. The experiments also demonstrate that MKLclm outperforms the standard SVM method using data from individual domains, as well as the traditional MKL method, showing that this deeper integration of data from different informatics domains can lead to significant gains in holistic glaucoma diagnosis and screening
Multiple ocular diseases detection by graph regularized multi-label learning
Get PDFWe develop a general framework for multiple ocular diseases diagnosis, based on Graph Regularized Multi-label Learning (GRML). Glaucoma, Pathological Myopia (PM), and Age-related Macular Degeneration (AMD) are three leading ocular diseases in the world. By exploiting the correlations among these three diseases, a novel GRML scheme is investigated for a simultaneous detection of these three leading ocular diseases for a given fundus image. We validate our GRML framework by conducting extensive experiments on SiMES dataset. The results show area under curve (AUC) of the receiver operating characteristic curve in multiple ocular diseases detection are much better than traditional popular algorithms. The method could be used for glaucoma, PM, and AMD diagnosis
The luminescence dating chronology of a deep core from Bosten Lake (NW China) in arid central Asia reveals lake evolution over the last 220Â ka
Get PDFDown-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer
Get PDFAn 88Â ka temperature record from a subtropical lake on the southeastern margin of the Tibetan Plateau (third pole): new insights and future perspectives
Full text linkPopulation inversion study of GaAs/AlGaAs three-quantum-well quantum cascade structures
Full text linkFluid-Structure Coupling Analysis for the Flow Distribution Device of Nuclear Reactor Internals
Full text linkIn order to better understand the stresses to which the flow distribution device (FDD) is subjected for the pressure fluctuation, we need to improve our knowledge of the fluid flow inside the reactor pressure vessel (RPV). The flow field of the reactor lower plenum which is associated with a typical pressurized water reactor (PWR) is simulated by using ANSYS CFX code. Calculations have been carried out from reactor pressure vessel inlet to the core outlet. Grid sizes of million nodes with the k-epsilon turbulent model have been used with a porous zone approach for the reactor core space. Predictions of the steady-state pressure and velocity field have been made. The results are compared with the scaled experiment data in order to verify the accurate description of the fluid flow. Based on this verified turbulent model, a sub-domain is extracted from the lower plenum for the transient two-way Fluid-Structure Interaction (FSI) simulation which is limited by the computer capability and computing time. This transient analysis of fluid-structure coupling system is conducted by using CFX and ANSYS in numeric calculation of flow field and structure, with an exchanging platform MFX-ANSYS/CFX which can transfer fluid pressure and structure displacement between computational fluid dynamics (CFD) and computational structure dynamics (CSD) grid systems. The loose coupling method is used to investigate the transient dynamic response of the flow distribution device which is immerged in the bottom plenum. Dynamic stress and strain of the flow distribution device are given and discussed. This analysis practice can be guidance for the optimization design of reactor and improve our understanding of reactor components flow induced vibration phenomena.</jats:p
CHIP-mediated CIB1 ubiquitination regulated epithelial–mesenchymal transition and tumor metastasis in lung adenocarcinoma
No full textAbstractCIB1 is a homolog of calmodulin that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in many tumor cells; however, its role in lung adenocarcinoma (LAC) has not been studied. In this study, the expression levels of CIB1 in LAC tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed. The effects of CIB1 on epithelial–mesenchymal transition (EMT), migration, and metastasis of LAC cells were determined in vitro and vivo. Proteins interacting with CIB1 were identified using electrospray mass spectrometry (LS-MS), and CHIP was selected in the following assays. Carboxyl-terminus of Hsp70-interacting protein (CHIP) is a ubiquitin E3 ligase. We show that CHIP can degrade CIB1 via promoting polyubiquitination of CIB1 and its subsequent proteasomal degradation. Besides, lysine residue 10 and 65 of CIB1 is the ubiquitinated site of CIB1. Furthermore, CHIP-mediated CIB1 downregulation is critical for the suppression of metastasis and migration of LAC. These results indicated that CHIP-mediated CIB1 ubiquitination could regulate epithelial–mesenchymal and tumor metastasis in LAC.</jats:p
Day Surgery unit Robotics Thoracic surgery: feasibility and management
No full textAbstract
Background:Day surgery has been widely carried out in medical developed countries such as Europe and the United States with high efficiency, safety and economy. The development of thoracic day surgery started late, and currently only a few top three hospitals carry thoracic day surgery. In recent years, with the continuous in-depth application of the concept of accelerated rehabilitation surgery (ERAS) in the field of surgery, thoracic surgery ERAS has also entered clinical practice with remarkable results. At present, the application of day surgery in the field of thoracic surgery is still in its infancy, and the application of robot-assisted thoracic surgery in thoracic surgery has brought new opportunities for the popularization of day surgery in thoracic surgery.
Methods: We retrospectively reviewed 86 patients underwent thoracic day surgery under the application of robot-assisted surgery system and through systematic randomization method choose 86 patients underwent conventional thoracic surgery under the application of robot-assisted surgery system at our Institute between 2020 and 2022. We analyzed the clinical and pathological features between the two groups.
Results: The clinical feature of location of the nodules, the size of nodules, pN, histology and post-operative complications were homogenous between the two groups. The average age was significantly higher in the conventional mode group, the ratio of male patients and the patients with history of smoking were significantly lower in day-surgery mode group. The major surgical method in conventional mode group was lobectomy resection(48.8%). While the segmental resection was the major surgical in day surgery mode group. The hospital stay and the time of drain was significant longer in conventional mode group. And the total medical cost in conventional was more than day-surgery mode group. While the histology and post-operative complications were homogenous between the two group.
Conclusion: Before this, day surgery and robotics assistant surgery in thoracic surgery had been proved feasibility and safety. However, there was no report of day surgery unit robotics assistant thoracic surgery. Our clinical practice demonstrated that the method of day surgery unit robotics thoracic surgery is feasibility and safety enough.</jats:p
