596 research outputs found
The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions.
Get PDFThe 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection (AMR) and small vessel arteriopathy. Specific topics included the strengths and limitations of the current rejection grading system, the central role of microvascular injury in AMR and approaches to semiquantitative assessment of histopathologic and immunophenotypic indicators, the role of AMR in the development of cardiac allograft vasculopathy, the important role of serologic antibody detection in the management of transplant recipients, and the potential application of new molecular approaches to the elucidation of the pathophysiology of AMR and potential for improving the current diagnostic system. Herein we summarize the key points from the presentations, the comprehensive, open and wide-ranging multidisciplinary discussion that was generated, and considerations for future endeavors
Environmental differences between sites control the diet and nutrition of the carnivorous plant Drosera rotundifolia
Get PDFBackground and aims:
Carnivorous plants are sensitive to small changes in resource availability, but few previous studies have examined how differences in nutrient and prey availability affect investment in and the benefit of carnivory. We studied the impact of site-level differences in resource availability on ecophysiological traits of carnivory for Drosera rotundifolia L.
Methods:
We measured prey availability, investment in carnivory (leaf stickiness), prey capture and diet of plants growing in two bogs with differences in N deposition and plant available N: Cors Fochno (0.62 g m−2 yr.−1, 353 μg l−1), Whixall Moss (1.37 g m−2 yr.−1, 1505 μg l−1). The total N amount per plant and the contributions of prey/root N to the plants’ N budget were calculated using a single isotope natural abundance method.
Results:
Plants at Whixall Moss invested less in carnivory, were less likely to capture prey, and were less reliant on prey-derived N (25.5% compared with 49.4%). Actual prey capture did not differ between sites. Diet composition differed – Cors Fochno plants captured 62% greater proportions of Diptera.
Conclusions:
Our results show site-level differences in plant diet and nutrition consistent with differences in resource availability. Similarity in actual prey capture may be explained by differences in leaf stickiness and prey abundance
NGC 3576 and NGC 3603: Two Luminous Southern HII Regions Observed at High Resolution with the Australia Telescope Compact Array
Get PDFNGC 3576 (G291.28-0.71; l=291.3o, b=-0.7o) and NGC 3603 (G291.58-0.43;
l=291.6o, b=-0.5o) are optically visible, luminous HII regions located at
distances of 3.0 kpc and 6.1 kpc, respectively. We present 3.4 cm Australian
Telescope Compact Array (ATCA) observations of these two sources in the
continuum and the H90a, He90a, C90a and H113b recombination lines with an
angular resolution of 7" and a velocity resolution of 2.6 km/s. All four
recombination lines are detected in the integrated profiles of the two sources.
Broad radio recombination lines are detected in both NGC 3576 (DV_{FWHM}>= 50
km/s) and NGC 3603 (DV_{FWHM}>=70 km/s). In NGC 3576 a prominent N-S velocity
gradient (~30 km/s/pc) is observed, and a clear temperature gradient (6000 K to
8000 K) is found from east to west, consistent with a known IR color gradient
in the source. In NGC 3603, the H90a, He90a and the H113b lines are detected
from 13 individual sources. The Y^+ (He/H) ratios in the two sources range from
0.08+/-0.04 to 0.26+/-0.10. We compare the morphology and kinematics of the
ionized gas at 3.4 cm with the distribution of stars, 10 micron emission and
H_2O, OH, and CH_3OH maser emission. These comparisons suggest that both NGC
3576 and NGC 3603 have undergone sequential star formation.Comment: 24 pages, 12 Postscript figure
Boolean network model predicts cell cycle sequence of fission yeast
Get PDFA Boolean network model of the cell-cycle regulatory network of fission yeast
(Schizosaccharomyces Pombe) is constructed solely on the basis of the known
biochemical interaction topology. Simulating the model in the computer,
faithfully reproduces the known sequence of regulatory activity patterns along
the cell cycle of the living cell. Contrary to existing differential equation
models, no parameters enter the model except the structure of the regulatory
circuitry. The dynamical properties of the model indicate that the biological
dynamical sequence is robustly implemented in the regulatory network, with the
biological stationary state G1 corresponding to the dominant attractor in state
space, and with the biological regulatory sequence being a strongly attractive
trajectory. Comparing the fission yeast cell-cycle model to a similar model of
the corresponding network in S. cerevisiae, a remarkable difference in
circuitry, as well as dynamics is observed. While the latter operates in a
strongly damped mode, driven by external excitation, the S. pombe network
represents an auto-excited system with external damping.Comment: 10 pages, 3 figure
Omics phenotyping in heart failure:The next frontier
Get PDFThis state-of-the-art review aims to provide an up-to-date look at breakthrough omic technologies that are helping to unravel heart failure (HF) disease mechanisms and heterogeneity. Genomics, transcriptomics, proteomics, and metabolomics in HF are reviewed in depth. In addition, there is a thorough, expert discussion regarding the value of omics in identifying novel disease pathways, advancing understanding of disease mechanisms, differentiating HF phenotypes, yielding biomarkers for diagnosis or prognosis, or identifying new therapeutic targets in HF. The combination of multiple omics technologies may create a more comprehensive picture of the factors and physiology involved in HF than achieved by either one alone and provides a rich resource for predictive phenotype modelling. However, the successful translation of omics tools as solutions to clinical HF requires that the observations are robust and reproducible and can be validated across multiple independent populations to ensure confidence in clinical decision-making.</p
First polarised light with the NIKA camera
Full text linkNIKA is a dual-band camera operating with 315 frequency multiplexed LEKIDs
cooled at 100 mK. NIKA is designed to observe the sky in intensity and
polarisation at 150 and 260 GHz from the IRAM 30-m telescope. It is a
test-bench for the final NIKA2 camera. The incoming linear polarisation is
modulated at four times the mechanical rotation frequency by a warm rotating
multi-layer Half Wave Plate. Then, the signal is analysed by a wire grid and
finally absorbed by the LEKIDs. The small time constant (< 1ms ) of the LEKID
detectors combined with the modulation of the HWP enables the
quasi-simultaneous measurement of the three Stokes parameters I, Q, U,
representing linear polarisation. In this paper we present results of recent
observational campaigns demonstrating the good performance of NIKA in detecting
polarisation at mm wavelength.Comment: 7 pages, Proceeding for Journal of Low Temperature Physic
A multi-wavelength polarimetric study of the blazar CTA 102 during a Gamma-ray flare in 2012
Full text linkWe perform a multi-wavelength polarimetric study of the quasar CTA 102 during
an extraordinarily bright -ray outburst detected by the {\it Fermi}
Large Area Telescope in September-October 2012 when the source reached a flux
of F photons cm s.
At the same time the source displayed an unprecedented optical and NIR
outburst. We study the evolution of the parsec scale jet with ultra-high
angular resolution through a sequence of 80 total and polarized intensity Very
Long Baseline Array images at 43 GHz, covering the observing period from June
2007 to June 2014. We find that the -ray outburst is coincident with
flares at all the other frequencies and is related to the passage of a new
superluminal knot through the radio core. The powerful -ray emission is
associated with a change in direction of the jet, which became oriented more
closely to our line of sight (1.2) during the ejection of
the knot and the -ray outburst. During the flare, the optical polarized
emission displays intra-day variability and a clear clockwise rotation of
EVPAs, which we associate with the path followed by the knot as it moves along
helical magnetic field lines, although a random walk of the EVPA caused by a
turbulent magnetic field cannot be ruled out. We locate the -ray
outburst a short distance downstream of the radio core, parsecs from the black
hole. This suggests that synchrotron self-Compton scattering of near-infrared
to ultraviolet photons is the probable mechanism for the -ray
production.Comment: Accepted for publication in The Astrophysical Journa
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