4,373 research outputs found
Mechanismus der enzymatischen Freisetzung von Acetaldehyd aus “aktivem Acetaldehyd” (α-hydroxyaethyl-2-thiaminpyrophosphat)
Get PDF1. 1.Die Freisetzung von Acetaldehyd aus “Aktivem Acetaldehyd” mit gereinigter Apopyruvatdecarboxylase aus Bierhefe wird durch. Thiaminpyrophosphat gehemmt. Diese Konkurrenzhemmung erklärt (zumindest teilweise) die langsame Freisetzung von Acetaldehyd beim enzymatischen Umsatz von Präparaten, die viel Thiamin-pyrophosphat enthalten.
2. 2. Die Freisetzung von Acetaldehyd aus “Aktivem Acetaldehyd” mit Apo-carboxylase erfolgt nicht in einer früher von uns diskutierten Austauschreaktion mit Pyruvat, sondern in einer direkten Reaktion: Aktiver Acetaldehyd å Acetaldehyd + TPP.1. 1. The enzymic formation of acetaldehyde from α-hydroxyethyl thiamine pyrophosphate with purified apopyrubate decarboxylase from yeast is inhibited by thiamine pyrophosphate. This inhibition explains (at least partly) the slow enzymic production of acetaldehyde from α-hydroxyethyl thiamine pyrophosphate preparations containing a considerable amount of thiamine pyrophosphate.
2. 2. The enzymic formation of acetaldehyde from α-hydroxyethyl thiamine pyrophosphate with apocarboxylase does not take place in form of an exchange reaction with pyruvate, as discussed earlier, but in form of the direct reaction: α-hydroxyethyl thiamine pyrophosphate → acetaldehyde + thiamine pyrophosphate
Wirkung carcinostatischer äthylenimin-verbindungen auf den DPN-gehalt therapieresistener tumoren
Get PDFPreliminary experiments with the ascites form of the relatively therapeutic-resistant DS-tumour demonstrated that the decrease in DPN content and the inhibition of glycolysis in the neoplastic cells under the influence of ethylenimine compounds were delayed, in comparison with the rapid changes observed in Ehrlich-ascites carcinomas. Extending these observations, the therapeutic effect of carcinostatic ethylenimine compounds was studied in rats bearing solid forms of either the Jensen sarcoma or the therapeutic-resistant DS-tumour. During the course of the experiments the DPN content of the tumours was followed. In the Jensen sarcoma the DPN content decreased sharply as early as the first day following administration of the carcinostatic, while the DS-tumour, in contrast, showed no clear change during the first six days. A cure was obtained in nine out of thirteen cases of the Jensen-sarcoma rats, while no cure was observed in six DS-tumour-bearing rats. These experiments further support our hypothesis, that carcinostatic ethylenimine compounds are therapeutically effective though they depress the DPN content in the tumour
Interleukin-1Ăź enhances capsaicin-induced neurogenic vasodilatation in the rat skin
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Rabies prophylaxis after an animal attack that caused a ruptured eye and traumatic cataract: a case report
Get PDFIntroduction: We report on a patient with an animal bite eye injury, his surgical treatment and proper rabies immunoglobulin administration. Case presentation: A 33-year-old Turkey hunter was attacked by a bobcat and his injuries included a ruptured globe with corneal laceration, two iris sphincter tears, and a ruptured anterior capsule with a traumatic cataract. Rabies vaccination was started, primary closure of the corneal laceration, an anterior chamber washout and one week later cataract surgery were performed. Three months postoperatively he achieved an uncorrected visual acuity of 20/50 and a best corrected visual acuity of 20/20. Conclusion: Bobcat attacks on humans are very rare and extremely suspicious for rabies infection of the animal. Ophthalmologists need to be aware of the importance of immediate and appropriate post exposure rabies vaccination. Proper rabies immunoglobulin administration in the setting of globe injuries is challenging and we report on the Center for Disease Control and Prevention recommendations for globe injuries
Particles held by springs in a linear shear flow exhibit oscillatory motion
Get PDFThe dynamics of small spheres, which are held by linear springs in a low
Reynolds number shear flow at neighboring locations is investigated. The flow
elongates the beads and the interplay of the shear gradient with the nonlinear
behavior of the hydrodynamic interaction among the spheres causes in a large
range of parameters a bifurcation to a surprising oscillatory bead motion. The
parameter ranges, wherein this bifurcation is either super- or subcritical, are
determined.Comment: 4 pages, 5 figure
Towards Collaborative Conceptual Exploration
Full text linkIn domains with high knowledge distribution a natural objective is to create
principle foundations for collaborative interactive learning environments. We
present a first mathematical characterization of a collaborative learning
group, a consortium, based on closure systems of attribute sets and the
well-known attribute exploration algorithm from formal concept analysis. To
this end, we introduce (weak) local experts for subdomains of a given knowledge
domain. These entities are able to refute and potentially accept a given
(implicational) query for some closure system that is a restriction of the
whole domain. On this we build up a consortial expert and show first insights
about the ability of such an expert to answer queries. Furthermore, we depict
techniques on how to cope with falsely accepted implications and on combining
counterexamples. Using notions from combinatorial design theory we further
expand those insights as far as providing first results on the decidability
problem if a given consortium is able to explore some target domain.
Applications in conceptual knowledge acquisition as well as in collaborative
interactive ontology learning are at hand.Comment: 15 pages, 2 figure
Politik i det refleksive moderne: fra livspolitik til subpolitik
Get PDFTemaets tredje artikel – Boris Holzer og Mads P. Sørensens artikel ”Politik i det refleksive moderne: fra livspolitik til subpolitik” tager Becks begreb om subpolitik under behandling
EHR-Based Care Coordination Performance Measures in Ambulatory Care
Get PDFDescribes electronic health record-based measures for assessing coordination in referrals, including information communicated with referral, communication to patient, and specialist report to primary care physician. Offers preliminary evaluation findings
Phase Rotation, Cooling And Acceleration Of Muon Beams: A Comparison Of Different Approaches
Get PDFExperimental and theoretical activities are underway at CERN with the aim of
examining the feasibility of a very-high-flux neutrino source. In the present
scheme, a high-power proton beam (some 4 MW) bombards a target where pions are
produced. The pions are collected and decay to muons under controlled optical
condition. The muons are cooled and accelerated to a final energy of 50 GeV
before being injected into a decay ring where they decay under well-defined
conditions of energy and emittance.
We present the most challenging parts of the whole scenario, the muon
capture, the ionisation-cooling and the first stage of the muon acceleration.
Different schemes, their performance and the technical challenges are compared.Comment: LINAC 2000 CONFERENCE, paper ID No. THC1
Trends and correlates of marijuana use among late middle-aged and older adults in the United States, 2002–2014
Full text linkBACKGROUND: Recent trend studies suggest that marijuana use is on the rise among the general population of adults ages 18 and older in the United States. However, little is known about the trends in marijuana use and marijuana-specific risk/protective factors among American adults during the latter part of adulthood.
METHOD: Findings are based on repeated, cross-sectional data collected from late middle-aged (ages 50–64) and older adults (ages 65 and older) surveyed as part of the National Survey on Drug Use and Health between 2002 and 2014.
RESULTS: The prevalence of past-year marijuana use among late middle-aged adults increased significantly from a low of 2.95% in 2003 to a high of 9.08% in 2014. Similarly, the prevalence of marijuana use increased significantly among older adults from a low of 0.15% in 2003 to a high of 2.04% in 2014. Notably, the upward trends in marijuana use remained significant even when accounting for sociodemographic, substance use, behavioral, and health-related factors. We also found that decreases in marijuana-specific protective factors were associated with the observed trend changes in marijuana use among late middle-aged and older adults, and observed a weakening of the association between late-middle aged marijuana use and risk propensity, other illicit drug use, and criminal justice system involvement over the course of the study.
CONCLUSIONS: Findings from the present study provide robust evidence indicating that marijuana use among older Americans has increased markedly in recent years, with the most evident changes observed between 2008 and 2014
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