147 research outputs found
Development of video tests for elementary school physical education to assess pupil’s ability to think and judge: Utilization of simultaneously reproduced four-split screen videos
Get PDFThis study is a follow-up report of a study by Osedo et al. (2018), wherein a video test in which pupils “think and judge” based on the knowledge gained in physical education classes was developed. In this study, we developed a new video test that simultaneously reproduces video images with two technical differences on a four-split screen. We then administered a survey to third grade students to examine whether there were any differences in their viewpoints when observing the video.
The results from an analysis of the data suggest that if a teacher wants his or her students to “think and judge” based on the observation of physical exercise from several viewpoints, a four-split screen video acts as a teaching material that requires more comprehensive “thinking and judging” as compared to Osedo et al.’s (2018) test. However, because of the increase in the number of video images, students may have developed dispersed observation viewpoints; therefore, a further examination of developmentally appropriate utilization methods is necessary.本研究は，日本学術振興会科研費の助成（16K01619）を受けたものです
Hyalinizing clear cell carcinoma with EWSR1 rearrangement in an 11-year-old girl
Get PDFHyalinizing clear cell carcinoma is a low-grade salivary gland carcinoma of epithelial origin comprised of malignant cells with clear cytoplasm and often surrounded by hyalinizing stroma. Hyalinizing clear cell carcinoma reportedly occurs in patients with a wide range of ages; however, no reports have been published in children. We herein report a rare case of hard palate hyalinizing clear cell carcinoma with EWSR1 rearrangement in an 11-year-old girl. The patient was referred to our hospital for further evaluation of a growing tumor in the hard palate. After performing biopsy, clear cell odontogenic carcinoma was suspected, although a definitive diagnosis could not be reached. The lesion was clinically suspected to be a salivary gland tumor and resected under general anesthesia. Histopathological evaluation revealed minor salivary gland carcinoma with clear cells and hyalinizing stroma with identification of EWSR1 rearrangement by fluorescence in situ hybridization. Thus, we diagnosed this patient with hyalinizing clear cell carcinoma. Hyalinizing clear cell carcinoma in children is rare, and there has been no evidence of recurrence or metastasis in our patient at 36 months postoperatively.http://purl.org/coar/resource_type/c_650
Malabaricone C as natural Sphingomyelin Synthase Inhibitor against diet-induced obesity and its lipid metabolism in mice
Get PDFThe interaction between natural occurring inhibitors and targeted membrane proteins could be an alternative medicinal strategy for the treatment of metabolic syndrome, notably, obesity. In this study, we identified malabaricones A–C and E (1–4) isolated from the fruits of Myristica cinnamomea King as natural inhibitors for sphingomyelin synthase (SMS), a membrane protein responsible for sphingolipid biosynthesis. Having the most promising inhibition, oral administration of compound 3 exhibited multiple efficacies in reducing weight gain, improving glucose tolerance, and reducing hepatic steatosis in high fat diet-induced obesity mice models. Liver lipid analysis revealed a crucial link between the SMS activities of compound 3 and its lipid metabolism in vitro and in vivo. The nontoxic nature of compound 3 makes it a suitable candidate in search of drugs which can be employed in the treatment and prevention of obesity
Early gastric cancer metastasizing to the rectum, possibly via a hematogenous route: a case report and review of literature
Get PDFBACKGROUND: The most common pattern of recurrence of gastric cancer (GC) is peritoneal dissemination. However, rectal metastasis via hematogenous or lymphatic spread is exceedingly rare. We present a case of a 65-year-old man with an intramucosal GC who developed a rectal recurrence, possibly via a hematogenous route. CASE PRESENTATION: A 65-year-old man underwent curative endoscopic submucosal dissections for the intramucosal GCs at the anterior wall of the fornix twice. The third GC at the similar location was treated by radical laparoscopic proximal gastrectomy; microscopic examination revealed well-differentiated tubular adenocarcinoma confined to the lamina propria mucosae (T1aN0M0, stage IA). Follow-up colonoscopy revealed a 30-mm submucosal mass in the rectal wall 2 years later, and a metastasis of gastric origin was suspected histopathologically. After a staging laparoscopy confirmed the absence of findings suggestive of serosal involvement or peritoneal dissemination, including negative peritoneal washing cytology, a laparoscopic low anterior resection with lymph node dissection was performed. Microscopically, the tumor was found to mainly be located in the submucosal layer and showed features of moderately differentiated tubular adenocarcinoma. The serosal surface was free of disseminated tumor. Lymph node metastases were identified. Immunohistochemically, there were foci of carcinoma cells that were positive for cytokeratin 20; however, they were negative for cytokeratin 7. Negative staining for caudal-type homeobox 2, a transcription factor indicating goblet cell differentiation, combined with absence of intramucosal carcinoma in the rectal mucosa, suggested a diagnosis of metastatic adenocarcinoma of gastric origin. The absence of evidence of peritoneal dissemination suggested hematogenous or lymphatic spread. CONCLUSION: Although rectal metastasis from GC, particularly when attributable to hematologic or lymphatic metastasis, is very rare, metastatic gastric adenocarcinoma should be considered as a differential diagnosis for patients who present with a rectal tumor and a past history of GC, even if it is an early GC
Size-Dependent Carrier Dynamics in CdS Nanoparticles by Femtosecond Visible-Pump/IR-Probe Measurements
Get PDFUltrafast photoexcited carrier dynamics in CdS nanoparticles prepared by an AOT/n-heptane reversed micelle system were investigated by a femtosecond visible-pump/mid-IR probe technique. A mid-IR probe beam was found to mainly probe the ultrafast dynamics of photoexcited electrons in the conduction band. Dispersions of CdS nanoparticles with 8 different mean diameters from 2.9 to 4.1 nm were prepared by tuning the mole ratio between water and AOT (W = [H2O]/[AOT]) in the reversed micelle systems. The excited state lifetime strongly depended on the mean size of CdS nanoparticles with a maximum around a mean diameter of 3.5 nm. This result was explained by considering the balance between the carrier recombination rates via surface states and those via interior states. The relationship between the excited state lifetime and the size of CdS nanoparticles was drastically changed when the surface was terminated by thiol molecules
520 Effect of Mean Stress and Combined Stress on Fatigue Strength of Zr-based Bulk Metallic Glass
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