421947 research outputs found
Sort by
Drug utilization study of mood stabilizers and antipsychotics drugs among bipolar disorder patients
No full textA key component of SDG 3, which is about good health and wellbeing, is mental illness. The burden of disease and mental illness is a priority for global development. Bipolar is a mental illness that causes unusual changes in mood, energy, physical activity, and concentration. Combinations of mood stabilizers and antipsychotic drugs have significantly altered the long-term prognosis for bipolar patients. This study aims to evaluate the drug utilization of mood stabilizers and antipsychotics in bipolar disorder patients. We conducted a retrospective, descriptive, hospital-based cross-sectional study among bipolar patients attending the psychiatric department at Hospital X, Yogyakarta, Indonesia, from January to May 2017. This study employed two methods to analyse the data: calculating the percentage of rational prescriptions and computing based on the defined daily dose (DDD) per 1000 patient days. In this study, there were 28 respondents between the ages of 26 and 46, with 98 total bipolar cases. 53.6% of participants were female, while 46.4% were male. The rational use of the concurrent administration of mood stabilizers and antipsychotics to patients with bipolar disorder was as follows: 69.39% precise use, 90.82% precise dose, 98.98% precise indication, 76.53% precise patient, and 76.53% precise drug. The result showed that mood stabilizer lithium had the lowest total annual consumption of 2.15 DDD/1000 outpatient visits, and sodium divalproex had the highest total annual consumption of 26.66 DDD/1000 outpatient visits. Risperidone was the antipsychotic with the highest quantity, at 25.92% DDD/1000 outpatient visits, while trifluoperazine had the lowest, at 0.17% DDD/1000 outpatient visits
Retraction notice: Volume removed – Publisher’s Disclaimer
No full textThis proceeding volume has been retracted from the publication because we found some solid reasons to believe that it has infringed our integrity criteria and now presents a risk for our journal and scholarly science in general. Different types of malpractice are involved, in particular citation manipulation and inappropriate references. We are extremely concerned by such malpractice which considerably impacts the image of our title and our Publisher’s reputation.
For further details, please refer to our publishing ethics policie
Slow release urea nitrate with starch polymer coating technique for fermentation and rumen digestibility in vitro
No full textThe present study was aimed to evaluate the effect of starch polymer coating. The starch used are divided into two, i.e., sago starch and cassava starch. A randomized complete block design was utilized in this study consisted of five treatments and four replications. The treatments are T0 = control diet; T1 = T0 + uncoated urea; T2 = T0 + uncoated urea-nitrate; T3 = T0 + urea- nitrate with sago starch coating; T4 = urea-nitrate with cassava starch coating. The urea-nitrate supplementation treatments with starch coating were expected to enhance dietary crude protein by 2% of the control diet and slow down the release of the diet in the rumen. Results revealed that T4 treatments reduced ammonia concentration compared to T0, T1, T2, and T3 (P<0.05). However, other parameters such as rumen pH, volatile fatty acid, microbial protein synthesis, dry matter digestibility, organic matter digestibility, total gas production, and methane production were similar among the treatments. In conclusion, the urea-nitrate supplementation with cassava starch coating in ruminant diet might slow down the release of ammonia in the rumen in vitro
Applied of bioinformatics in drug discovery and drug development: Bioinformatic analysis 1996-2024
No full textDrug discovery and drug development were two complex process to find new drugs. Advance science of medicine after human genome project were established accelerating the development of new field called bionformatics. Currently, bioinformatics integrated multidisciplinary studies including molecular biology, mathematics and information engineering. This study utilized the Biblioshiny and VosViewer databases as well as the Scopus database to evalute the study related to the bioinformatics in Drug Discovery and Drug Development. Our study were analyzed the scopus data which were retrieved from 1996-2024. We highlighted that 1581 research articles which were publised in 701 journals. Our findings showed that the annual grow up of the research related study was increased annually with the peak of study in 2023. Besides, top five most relevant sources of study was PlosOne (32 documents), international journal of molecular sciences (30 documents), BMS Bioinformatics (29 documents), Bioinfromatics (24 documents), and Frontiers in Genetics (19 documents). In conclusion, through the integration of the use of Vosviewer, biblioshiny and Scopus database software, our findings show a positive trend regarding research on the application of bioinformatics in drug discovery and drug development
Association between allergic rhinitis and chronic rhinosinusitis on multislice computed tomography scan paranasal sinuses
No full textRhinosinusitis is inflammation sinus mucosa, which is generally triggered by rhinitis, therefore it’s often called rhinosinusitis. Some predisposing factors include acute respiratory infection due to viruses, various rhinitis, especially allergic rhinitis. As many as 50 patients underwent MSCT-Scan SPN examinations in 2022 at PKU Muhammadiyah Bantul. This research uses quantitative research methods with a cross-sectional analytical approach. The sampling technique in this research used total sampling. The data analysis used is univariate and bivariate analysis with the chi-square statistical test. From 47 samples, 25 people (53.2%) suffered from allergic rhinitis, 42 people (89.4%) suffered from chronic rhinosinusitis. Female patients showed the most chronic rhinosinusitis features on MSCT-Scan Paranasal Sinuses examination as many as 24 people (57.31%), with the highest age being 36-45 years as many as 14 people (33.3%). The highest frequency of chronic rhinosinusitis features was the unilateral maxillary type with 31 cases (18.6%). The calculation results of the relationship between chronic rhinosinusitis show a P-Value of 0.352. We highlighted that there is no significant relationship between allergic rhinitis and chronic rhinosinusitis on MSCT-Scan Paranasal Sinuses at PKU Muhammadiyah Bantul for the period January-December 2022
The role of estuarine wetland in carbon storage for climate change mitigation: A bibliometric analysis
No full textThe 2023 progress report on the Sustainable Development Goals (SDGs) is weak, even regressing, including key targets related to climate change, and at risk of failure. Estuarine ecosystems dominated by mangrove vegetation are critical for climate change mitigation. However, these ecosystems continue to be degraded at multiple levels. Indonesia, with the largest mangrove forest area in the world, requires conservation and restoration efforts to effectively mitigate climate change impacts. This study aims to analyze the role of estuarine ecosystems in storing carbon for climate change mitigation. This research uses bibliometric analysis method to produce an in-depth and comprehensive analysis. The data source is the Scopus database, visualized using the VOSviewer application. After limitation, 219 out of 1485 documents that fit the inclusion criteria were obtained. The results showed a significant increase in interest in the topic of the role of estuarine ecosystems for climate change mitigation in the last two years. This research underscores the importance of mangroves restoration in estuarine ecosystems, as their condition has significant impacts on climate change and coastal communities. Nature-based solutions such as the use of green energy, implementation of new technologies such as remote monitoring, and ecosystem balance-based policy-making are recommended. The integration of multi-disciplinary and multi-technology approaches is crucial to build resilient, natural estuarine ecosystems and restore ecosystem services. These findings can also provide a scientific basis for the management of estuarine ecosystems to support SDG 13 Climate Action
On the exact Maxwell evolution equation of resonator dynamics
No full textIn a recent publication [Opt. Express 32, 20904 (2024)], the accuracy of the main evolution equation that governs resonator dynamics in the coupled-mode theory (CMT) was questioned. The study concluded that the driving force is proportional to the temporal derivative of the excitation field rather than the excitation field itself. This conclusion was reached with a derivation of an “exact” Maxwell evolution (EME) equation obtained directly from Maxwell’s equations, which was further supported by extensive numerical tests. Hereafter, we argue that the original derivation lacks mathematical rigor. We present a direct and rigorous derivation that establishes a solid mathematical foundation for the EME equation. This new approach clarifies the origin of the temporal derivative in the excitation term of CMT and elucidates the approximations present in the classical CMT evolution equation through a straightforward argument
ϵ-Nash equilibrium of anticipative large-population LQ game with partial observations
No full textIn this paper, we study a class of large-population linear-quadratic game problem that is driven by an anticipative signal-observation system with a correlation between the initial value of the signal and the observation noise. Firstly, we utilize a method of enlargement of filtration to transform the anticipative signal-observation system into a higher-dimensional non-anticipative one, and construct an extended equivalent large-population adapted game problem. Secondly, for each individual, by separation principle, filtering theory, and squared compensatory technology, we derive a closed-form decentralized equilibrium strategy for a limiting adapted version with a freezing term instead of average state, and obtain a consistency condition consisting of a forward-backward stochastic differential system with the coefficients affected by the correlation function. Finally, we prove for the extended equivalent large-population adapted game, the ϵ-Nash equilibrium properties of the decentralized strategy designed by means of locally observed information
Phenology and morphology of cucumber hybrids in greenhouses
No full textThe aim of the experiment was to select high-yielding cucumber (Cucumus sativus L.) hybrids suitable for cultivation in unheated film greenhouses. In unheated film greenhouses, the morphological, biological and economic characteristics of 20 F1 cucumber hybrids were comprehensively evaluated, and it was found that Khan F1 (55 days) was superior in terms of early maturity; the standard fruit diameter for the Orzu F1 hybrid was 3.8 cm, while for all the studied hybrids it was 3.5–3.9 cm; plants were found to be 225 to 265 cm tall with 28 to 35 leaves; the total weight of fruits per plant during the period of technical ripeness of fruits was 4.7 kg in the control Orzu F1 hybrid, and Dayara F1, Sardor F1, Fontina F1 hybrids were 111.1–114.8% higher than the control, or 5.2–5.4 kg; in terms of yield, Fontina F1, Dayara F1 and Sardor F1 hybrids were 16.2–16.7 kg/m2 or 111.0–114.8% higher than the standard